Pair Name	Honokiol, Paclitaxel
Disease Info	[ICD-11: 2C25]	Lung cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation	Up-regulation	Expression	ATF4	hsa468
	Up-regulation	Expression	CDKN1A	hsa1026
	Up-regulation	Expression	DDIT3	hsa1649
	Up-regulation	Phosphorylation	EIF2S1	hsa1965
	Up-regulation	Expression	HSPA5	hsa3309
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Up-regulation	Phosphorylation	MAPK1	hsa5594
	Up-regulation	Phosphorylation	MAPK8	hsa5599
	Up-regulation	Expression	MCL1	hsa4170
	Up-regulation	Expression	NKRF	KEGG ID N.A.
	Up-regulation	Expression	PMAIP1	hsa5366
	Up-regulation	Expression	PSMD9	hsa5715
	Up-regulation	Expression	PTEN	hsa5728
	Up-regulation	Expression	XBP1	hsa7494
In Vitro Model	NCI-H1650	Minimally invasive lung adenocarcinoma	Homo sapiens (Human)	CVCL_1483
	NCI-H1299	Lung large cell carcinoma	Homo sapiens (Human)	CVCL_0060
In Vivo Model	H1299 cells were washed three times with cold PBS and suspended at a final concentration of 1×10⁷/ml in PBS. Next 100 µl cell suspensions were subcutaneously injected into the right flanks of the mice.
Result	Synergistic killing effect of paclitaxel and honokiol in non-small cell lung cancer cells through paraptosis induction